Five Elements Bio-technology Co., Ltd. , All rights reserved
GAN ICP NO.36585544-1
Holding the visions of “shielding people from fear of cancers; keeping people away from diseases; offering people affordable personalized medicine”, Five Elements bio-technology is in collaborations with domestic and foreign top-level teams of scientists and biotechnology companies, using the tumor organoid technology as our key technology. We are committed to introducing and promoting the cutting-edge concepts and technologies, designing and building a series of personalized healthcare services for our customers including precise screenings for tumor, guidance for treatment, and personalized healthcare management services featuring telomere and anti-aging technologies. Furthermore, Five Elements will collect and organize the data of treatment, diet, sports so as to achieve the purpose of storage, circulation, exchange of personal medical and health data by building a big data asset platform in which everyone can get involved and share.
We are not only a health care provider, but also a promoter of scientific concepts of health. The personalized healthcare platform we build is not just a production platform for healthcare services, but also a sharing platform where everyone can join, make contributions and create value, realizing the purpose of delaying senescence, staying away from the fear of cancers with telomere technology, enjoying affordable precision medicine with the personal data assets.
I Screening and diagnosis of diseases
1Genetic Test for Disease Susceptibility
Disease susceptibility test refers to the tendency of having a certain kind of disease determined by gene. Individuals with high disease susceptibility means that they carry susceptibility genes of a certain kind of disease. By collecting the genetic materials in the cells to have sequencing test or genetic typing test, we can detect the pathogenic genes or susceptibility genes to evaluate the risk of having this kind of disease.
Healthy people and sub-healthy people with the demand of disease susceptibility test
1 Detection of oncogene disease: including 26 cancers, such as, lung cancer, gastric cancer, liver cancer, breast cancer, prostrate cancer.
2 Whole genome sequencing test: including 43 chronic diseases, such as atherosis, diabetes type II, 26 cancers, such as lung cancer, gastric cancer.
Circulating Tumor Cell Detection Service
CTC refers to the cells that have shed into the vasculature or lymphatics from a primary tumor and are carried around the body in the blood circulation.
The Clinical significance of CTC detection is mainly reflected in the early diagnosis. It can provide more accurate and early diagnosis than PET, MRI,ctDNA can provide. Besides, CTC detection is good for making the prognostic judgement and can offer guidance for therapeutic schemes by making prognostic judgement and estimating the survival time according to the number of the CTCs before and after the treatment. It can also apply to the detections of tumor recurrence and drug resistance, effectiveness evaluations of chemotherapy drugs. Through in vitro 3D organoid cultures, tumor organoid models can be established to conduct anti-tumor drug sensitivity screenings and provide consultations for personalized medicine,
1 Healthy people with the demand of screening
2 Cancer patients, patients with lung cancer, colorectal cancer, rectal cancer or breast cancer
II Guidance for Tumor Treatment
1Whole Exome Sequencing
Whole exome sequencing is based on the second-generation gene sequencing technology which can detect 27000 human encoding genes. For the purpose of predicting the clinical effect of targeted anti-tumor drugs, we can screen the targeted drugs tailored to cancer patients’ genotype in a more effective, comprehensive approach and assist the doctor to choose the treatment with maximum curative effect and minimum side effect by conducting bioinformatic analysis and explanation, combing the clinical information of patients and the best existing clinical evidence.
Cancer patients with the demand of finding the effective targeted drugs for gastric cancer, colorectal cancer,pancreatic cancer, breast cancer, ovarian cancer.
Whole exome sequencing Bioinformatics analysis Medical history, Pathology results Clinical evidence of drugs Best treatment option
Personalized Circulating tumor DNA
ctDNA is tumor-derived fragmented DNA in the bloodstream that is not associated with cells. ctDNA may reflect the entire tumor genome. By performing the expansions and detections of CtDNA and combining with the whole exome sequencing results, we can screen a group of gene mutations highly associated with tumor from a large number of DNAS and integrate them with drug susceptibility and mutation of drug-resistance gene to provide the patients with the monitoring for mutation of drug-resistance gene and the monitoring for tumor activity.
Cancer patients who have already taken the whole exome sequencing and are with the demand of monitoring the recurrence or metastasis of tumor and mutation of drug-resistance gene
Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. Science 359, 920–926 (2018).
3Drug sensitivity test based on the patient-derived tumor organoids technology
Among all the anti-tumor drugs, up to 40% are non-targeted chemotherapeutics drugs, of which the effective rate is just 30%. So far, there is no effective drug sensitivity test for the individual therapy that aims at non-targeted drugs. Even for the targeted drugs, the gene sequencing test can’t predict the susceptibilities accurately.
The data in the chart is obtained from the medical documents in the Pudmed database, which represents personal views for reference only.
A tumor organoid is the microtumor model cultured in vitro using the isolated tumor cells from tumor tissues or tumor cells in the blood circulation. The tumor organoids deriving from the patients’ tumors can reflect the real situations of the tumors, which is the most direct and effective method for testing drug sensitivity (sensitivity is 100%, specificity is 93%). Drug sensitivity test based on the tumor organoids technology can apply to both the targeted and non-targeted anti-tumor drugs which compensates the deficiency that the gene sequencing test only predict the drug sensitivity of targeted drugs.
Drug sensitivity test based on the tumor organoid technology
Most of the patients aren’t fit for surgeries or biopsies, so the tumor specimens can’t be collected. It is difficult to analyze the features of the tumors to provide appropriate clinical treatments. The drug sensitivity test provided by Five Elements is not only for surgical patients but also for the non-surgical patients. For surgical patients, using the tumor tissues from surgeries to implement digestions to obtain tumor cells with which to conduct 3D cultures and expansions in vitro to establish a microtumor model. For non-surgical patients or patients, collect 5-10ml blood sample from vein, then isolate the tumor cells from blood so as to conduct 3D cultures and expansions in vitro to establish a microtumor model.
Patients-----blood sample or tumor tissues -------organoid culture--------- orgnoid expansion-------- anti-tumor drug susceptibility -------- precise antitumor treatment plan
This test applies to the cancer patients with the demand of drug sensitivity screening.
III Personalized healthcare management services
Telomeres are the caps at the end of each strand of DNA that protect our chromosomes. Our cells replenish by copying themselves. This happens constantly throughout our lives. Telomeres get shorter each time a cell copies itself. Eventually, telomeres get too short to do their job, causing our cells to age and stop functioning properly. Therefore, telomeres act as the aging clock in every cell.
In 2009, the Nobel Prize for Medicine was awarded to three American scientists who discovered how an enzyme called telomerase impacts telomere length, which uncovers the mystery of aging and cancers or age-related diseases.
Through measuring the average length and lengths distribution of the telomeres in chromosomes, we can measure the senescence of body. Having constant monitoring of the telomeres lengths, observations of the shortening speed of their average length, investigations of the percentage of short telomeres can reflect the aging speed of body. Telomere is a vital biomarker for evaluating health conditions.
Telomeres length and other telomere associated variables are known to be promising biomarkers in diagnostics and prognosis of cancers like protastic cancer, lung cancer.
1 Healthy people above the age of 18
2 People above the age of 35 and in the sub-health condition
2Fast Mimicking Diet
What is the purpose of measuring the telomere length and knowing the conditions of senescence? Is there any method of improvement?
Relieving pressure, healthy diet management, moderate exercise and scientific health management can reduce the speed of telomere shortening, even extend the lengths of the telomeres to some extent, thus, delaying the senescence and reducing the risk of having chronic diseases.
According to the reports in the international journals like Cell, Nature, Science, fast mimicking diet can prolong the lifespan of animals, prevent the chronic diseases, such as cardiovascular diseases, cancer and cognition impairment. BBC, a famous production company in Britain, used to make a documentary named Eating, fasting, live longer, in which they interviewed many nutritionist worldwide to explore the relationship between the fast mimicking diet and health, and report the fact that the fast mimicking diet can improve the health indexes.
Among all the healthy life styles, fast mimicking diet is highly praised by celebrities and socialites. Through controlling the intake of calories periodically, fast mimicking diet can regulate metabolism and improve health conditions.
Five Elements introduced the technology of telomere length monitoring to instruct the fast mimicking diet scientifically through observing the changes of telomeres. This diet intervention management model that combines with monitoring the changes of telomeres will enhance the intervention objects’ motivation and compliance significantly, which will help to delay the senescence, improve the health condition, and realize the purpose of chronic diseases prevention.
Fast Mimicking Diet Plan:
1 5:2 Diet plan, choose two days from a week to carry out fast mimicking diet and caloric intake restriction. Individuals are allowed to eat freely in the rest days of the week.
2 5-day diet plan, choose 5 days from a month to carry out fast mimicking diet and caloric intake restriction. Individuals are allowed to eat freely in the rest days of the month.
1 Healthy people above the age of 18
2 People above the age of 35 and in the sub-health condition
Immune Cell Biobanking
Immune cell is the best doctor in the world. As we age, both the quality and quantity of immune cells will decline. Storing the immune cells means storing the seeds of life, which will bring infinite possibilities to your health in the future.
The functions of immune cell biobanking
The immune cells in the biobank can be revived, expanded in vitro and transferred to body, which will apply to different immunological therapies.
1 anti-aging therapy, improvement of sub-health condition, primary prevention of diseases
2 antineoplastic therapy, the hope of cancer treatment
Immune cell biobanking plan:
1Target user: Healthy adults
2Sample source: Peripheral blood
3Storage type:mononuclear cell in peripheral blood
4Sample size:100-250ml,collect in multiple times
5Storage method:Liquid nitrogen storage with Ultra-low temperature (-196℃),maximum period of storage is 20 years. Customer can choose the period of storage according to their own situations.
If under good health condition, the immune cells storage can be conducted multiple times.
The service of exchanging the health data asset
In the data exchange market, your health data is far more valuable than the data of your credit cards, the value of your health data is beyond your imagination. The mission of Five Elements is more than providing high-quality healthcare service and improving your health status. We want to challenge the operating model of health industry, which transfer healthcare from a one-way consuming process into a channel creating benefits for individual patients. In order to realize our vision of offering people affordable precision medicine, Five Elements is dedicated to building a health data asset consortium based on AI and blockchain technology in which research centers, pharmaceutical companies, physical examination centers, hospitals, insurance companies, biotechnological companies will work as members.
We will establish electronic health records for our members and join the health data consortium. Based on the premise of protecting privacy, members can share their medical, dietary and sports information in order to gain credits with which they can exchange for medical services, therefore, realizing the capitalization and valorization of health data and making a significant contribution to healthcare industry.